QALYs in adults with cerebral palsy: Mapping from the San Martin Scale onto the EQ-5D-5L instrument

• DIANA M. NOVA DÍAZ ^[1] ; ARITZ ADIN ^[1] ; EDUARDO SÁNCHEZ IRISO ^[1]
  1. [1] Universidad Pública de Navarra

     Universidad Pública de Navarra

     Pamplona, España

     
• Localización: Documentos de trabajo ( FEDEA ), ISSN 1696-7496, Nº. 7, 2024, págs. 1-25
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Background: Responses on health-related quality of life measured by disease-specific instruments can be mapped onto the EQ-5D-5L to estimate utility values for economic evaluation. San Martin´s Quality of Life Scale (St. MQoL-S) is a preferred measure to obtain health outcomes in adults with cerebral palsy. Nevertheless, it lacks a preference-based health utility score for estimating quality-adjusted life years (QALYs).

    Objective: To develop algorithms for mapping from the St. MQoL-S to allow future prediction of the EQ-5D-5L, in adults with cerebral palsy, when utility data have not been collected.

    Methods: Direct mapping models were developed using ordinary least squares, a generalized linear model, and Tobit regression analysis to estimate EQ-5D-5L utilities, with St. MQoL-S total and domain scores as explanatory variables, in a cross-sectional study of adults with cerebral palsy in Spain. Goodness-of-fit was assessed using mean absolute error (MAE) and root mean square error (RMSE). Repeated k-fold cross-validation was employed to select the optimal mapping model demonstrating superior predictive performance.

    Results: The best-performing model for predicting EQ-5D-5L utilities, includes the St. MQoL- S total scores, age, gender, and types of cerebral palsy as explanatory variables in a stepwise ordinary least squares regression, making it the most robust model for use as a mapping algorithm with external data.

    Conclusion: This is the first study to present mapping algorithms between the St. MQoL-S and EQ-5D-5L. The mapping functions preferred in this study seem adequate for estimating the utilities of the EQ-5D-5L for economic evaluation and to obtain QALYs in adults with cerebral palsy.

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