A Randomized Two Stage Adaptively Censored Design With Application to Testing

• Autores: Uttam Bandyopadhyay, Rahul Bhattacharya
• Localización: Revista Colombiana de Estadística, ISSN-e 2389-8976, ISSN 0120-1751, Vol. 42, Nº. 2, 2019, págs. 209-224
• Idioma: inglés
• DOI: 10.15446/rce.v42n2.65344
• Títulos paralelos:
  • Un diseño aleatorio censurado adaptativo en dos etapas con aplicación
• Enlaces
  • Texto completo
• Resumen
  • español

    Resumen Se desarrolla un diseño aleatorizado en dos etapas para dos ensayos clínicos de tratamiento en los que las variables de respuesta son exponenciales y las observaciones se censuran utilizando la censura por fallo y la censura temporal en la primera y segunda etapas, respectivamente. El tiempo de censura para la segunda etapa se determina a partir de los resultados de la primera etapa. Una aplicación para probar la igualdad de efectos del tratamiento se da junto con un estudio comparativo con propiedades relevantes.

  • English

    Abstract A two stage randomized design is developed for two treatment clinical trials in which response variables are exponential and the observations are censored by using failure censoring and time censoring in the first and second stages respectively. The censoring time for the second stage is determined from the outcomes of the first stage. An application to testing for the equality of treatment effects is given along with a comparative study with relevant properties.

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