On quantitative trait locus mapping with an interference phenomenon

• Autores: Charles-Elie Rabier
• Localización: Test: An Official Journal of the Spanish Society of Statistics and Operations Research, ISSN-e 1863-8260, ISSN 1133-0686, Vol. 23, Nº. 2, 2014, págs. 311-329
• Idioma: inglés
• DOI: 10.1007/s11749-013-0349-z
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• Resumen

  • We consider the likelihood ratio test (LRT) process related to the test of the absence of QTL (a QTL denotes a gene with quantitative effect on a trait) on the interval [0, T] representing a chromosome. The observation is the trait and the composition of the genome at some locations called “markers”. We focus on the interference phenomenon, i.e. a recombination event inhibits the formation of another recombination event nearby. We give the asymptotic distribution of the LRT process under the null hypothesis that there is no QTL on [0, T] and under local alternatives with a QTL at t⋆ on [0, T]. We show that the LRT process is asymptotically the square of a “linear interpolated and normalized process”. We prove that under the null hypothesis, the distribution of the maximum of the LRT process is the same for a model with or without interference. However, the powers of detection are totally different between the two models