A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization

• Autores: Carlos Cabal Mirabal, Iván Ruiz Chaveco
• Localización: Integración: Temas de matemáticas, ISSN 0120-419X, Vol. 26, Nº. 1, 2008 (Ejemplar dedicado a: Revista Integración), págs. 13-22
• Idioma: inglés
• Títulos paralelos:
  • A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization
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• Resumen
  • español

    Los mecanismos de formación molecular agregada desempeña un papel importante en la interpretación de la patofisiología de la anemia de células falciformes (o anemia drepanocítica), y en la selección de las estrategias terapéuticas a seguir.  Aquí se propone un mecanismo y un modelo matemático. el modelo postula la existencia de microtúbulos defectivos formados por deoxihemoglobina S y oxihemoglobina S, y explica la dependencia de la polimerización de la concentración de hemoglobina, la temperatura y la presión parcial de oxígeno. El análisis hace énfasis en la polimerización de hemoglobina S en la ausencia de cristalización. La acción de otras clases de hemoglobinas en la formación molecular agregada puede ser explicada.

  • English

    The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow.  A mechanism and a mathematical model are proposed. The model postu-lates the existence of defective microtubules formed by deoxy hemoglobin S and oxy hemoglobin S, and explains the dependence of polymerization on hemoglobin concentration, temperature, and partial oxygen pressure. The analysis focuses on the polymerization of hemoglobin S in the absence of crystallization. The action of other kinds of hemoglobin in the molecular aggregate formation process can be explained.   

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