Resumen de Two alternative estimation procedures for the negative binomial cure rate model with a latent activation scheme

Diego I. Gallardo, Heleno Bolfarine

• In this paper two alternative estimation procedures based o n the EM algorithm are proposed for the flexible negative binomial cure rate model with a latent a ctivation scheme. The Weibull model as well as the log-normal and gamma distributions are also co nsidered for the time-to-event data for the non-destroyed cells. Simulation studies show the sa tisfactory performance of the proposed methodology. The impact of misspecifying the survival func tion on both components of the model (cured and susceptible) is also evaluated. The use of the new methodology is illustrated with a real data set related to a clinical trial on Phase III cutaneo us melanoma patients