Alteración del perfil lipídico y del riesgo cardiovascular en pacientes con Hipotiroidismo subclínico.

• Autores: María Antonia López Rubio, Pedro Juan Tárraga López , J. A. Rodríguez Montes, Carmen Frías López, Juan Solera Albero, Pablo Bermejo López
• Localización: Journal of Negative and No Positive Results: JONNPR, ISSN-e 2529-850X, Vol. 1, Nº. 2, 2016, págs. 45-49
• Idioma: español
• DOI: 10.19230/jonnpr.2016.1.2.970
• Títulos paralelos:
  • Altered lipid profile and cardiovascular risk in patients with subclinical hypothyroidism.
• Enlaces
  • Texto completo (pdf)
• Dialnet Métricas: 3 Citas
• Resumen
  • español

    Diversos estudios han puesto de manifiesto una teórica relación entre perfil lipídico pro-aterogénico e hipotiroidismo subclínico, lo quepodría plantear si éste último podría condicionar mayor riesgo cardiovascular.Objetivo: Establecer si existe asociación entre el hipotiroidismo subclínico y parámetros que pueden condicionar un mayor riesgocardiovascular o un perfil lipídico desfavorable.Métodos: Estudio transversal, realizado en la provincia de Albacete en enero de 2012 en pacientes con hipotiroidismo subclínico. Serecogieron parámetros analíticos, de exploración física y antecedentes personales. Posteriormente, se estimó el riesgo cardiovascularmediante Framingham.Resultados: No se hallaron aumento de los factores de riesgo cardiovascular. El valor de TSH en pacientes con LDL-colesterolpatológico estaba aumentado, sin significación estadística (p=0,412, IC 95% = [-0,45,- 0,179]). Tampoco se encontró relación entreTSH y colesterol total (p=0,641), HDL (p =0,931) o LDL (p=0,747). Solamente, se encontró asociación con un nivel patológico detriglicéridos (p=0,0004).Conclusiones: No existe relación entre el hipotiroidismo subclínico y mayor riesgo cardiovascular, aumento de factores de riesgocardiovascular o un perfil lipídico desfavorable, salvo para niveles patológicos de triglicéridos.

  • English

    Summary: Several studies have shown a theoretical relationship between pro-atherogenic lipid profile and subclinical hypothyroidism,which could rise if the latter could condition increased cardiovascular risk.Objective: To establish the association between subclinical hypothyroidism and parameters that can determine an increasedcardiovascular risk or an unfavorable lipid profile.Methods: Cross-sectional study conducted in the province of Albacete in January 2012 in patients with subclinical hypothyroidism.Laboratory parameters, physical examination and medical history were collected. Subsequently, cardiovascular risk was estimated byFramingham.Results: No increase in cardiovascular risk factors was found. The value of TSH in patients with pathological LDL-cholesterol wasincreased disease without statistical significance (p = 0.412, 95% CI [-0.45, - 0.179]). No relationship between TSH and totalcholesterol (p = 0.641), HDL (p = 0.931) or LDL (p = 0.747) was found. Only, association with a pathological level of triglycerides (p =0.0004) was detected.Conclusions: There is no relationship between subclinical hypothyroidism and increased cardiovascular risk, increased cardiovascularrisk factors or unfavorable lipid profile except for pathological levels of triglycerides.

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