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Toxicological risk assessment of complex mixtures through the Wtox model

  • Autores: William Gerson Matias, Letícia Flohr
  • Localización: Modelling in Science Education and Learning, ISSN-e 1988-3145, Vol. 8, Nº. 1, 2015, págs. 45-69
  • Idioma: inglés
  • DOI: 10.4995/msel.2015.2737
  • Títulos paralelos:
    • Avaliaçao do risco toxicológico de misturas complexas através do Modelo WTox
  • Enlaces
  • Resumen
    • español

      Modelos matemáticos sao importantes ferramentas de gestão ambiental e gerenciamento de riscos. Previsões sobre toxicidade de misturas químicas ainda devem ser aprimoradas, devido à complexidade de efeitos que podem causar aos seres vivos. Neste trabalho, avaliou-se risco ambiental abordando a necessidade do estudo da relação entre organismo e xenobióticos. Para isto, cinco tipos de testes toxicológicos foram aplicados através do Modelo WTox, e com esta metodologia foi possível obter a classificação do risco de substâncias potencialmente ttóxicas. Toxicidade aguda, crônica, citotoxicidade e genotoxicidade foram observadas nos organismos Daphnia magna, Vibrio scheri e Oreochromis niloticus. Um estudo de caso foi realizado com resíduos sólidos provenientes da indústria têxtil, metal-mecânica e de papel e celulose. Os resultados demonstraram que diversos resíduos induziram mortalidade, efeitos na reprodução, aumentos na taxa de lipoperoxidacao, mutações e alterações na mutilação do DNA dos organismos. Estes resultados, analisados através do Modelo WTox, permitiram a classificação de risco ambiental dos resíduos industriais. A avaliacao classificou as amostras como de risco ambiental toxicológico significativo ou crítico.

    • English

      Mathematical models are important tools for environmental management and risk assessment. Predictions about the toxicity of chemical mixtures must be enhanced due to the complexity of eects that can be caused to the living species. In this work, the environmental risk was accessed addressing the need to study the relationship between the organism and xenobiotics. Therefore, ve toxicological endpoints were applied through the WTox Model, and with this methodology we obtained the risk classication of potentially toxic substances. Acute and chronic toxicity, citotoxicity and genotoxicity were observed in the organisms Daphnia magna, Vibrio scheri and Oreochromis niloticus. A case study was conducted with solid wastes from textile, metal-mechanic and pulp and paper industries. The results have shown that several industrial wastes induced mortality, reproductive eects, micronucleus formation and increases in the rate of lipid peroxidation and DNA methylation of the organisms tested. These results, analyzed together through the WTox Model, allowed the classication of the environmental risk of industrial wastes. The evaluation showed that the toxicological environmental risk of the samples analyzed can be classied as signicant or critical.

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