Composite model of a hematopoietic system with clone competition

Autores: M. Rusinov, S. Kulikov, L. Uvarova
Localización: Computational methods and experimental measurements / G. M. Carlomagno (ed. lit.), Carlos A. Brebbia (ed. lit.) , Santiago Hernández (ed. lit.) , 2013, ISBN 978-1-84564-732-2, págs. 69-77
Idioma: inglés
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Resumen
- This paper is dedicated to the development of a human hematopoietic system model, its identification and investigation of the roles of polyclonal and complex feedback in defining the behavior of the system. The main purpose of the model framing is the study of the interaction and the possible pathogenetic role of simultaneously coexisting distinct lines of blood, which develop in parallel. The article proposes a classification system form human hematogenesis models based on following a key principle: the method of describing the age structure of cell population. Based on the analysis of said classification certain systems features, which have not been considered previously, stand out. To take them into account, we propose a model based on the McKendrick-von Foerster equation. This paper describes the features and limitations of this model and discusses further development of the model.