The asymptotic relative efficiency and the ratio of sample sizes when testing two different null hypotheses

• Autores: Guadalupe Gómez Melis , Moisés Gómez Mateu
• Localización: Sort: Statistics and Operations Research Transactions, ISSN 1696-2281, Vol. 38, Nº. 1, 2014, págs. 73-88
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Composite endpoints, consisting of the union of two or more outcomes, are often used as the primary endpoint in time-to-event randomized clinical trials. Previously, Gómez and Lagakos provided a method to guide the decision between using a composite endpoint instead of one of its components when testing the effect of a treatment in a randomized clinical trial. Consider the problem of testing the null hypotheses of no treatment effect by means of either the single component or the composite endpoint. In this paper we prove that the usual interpretation of the asymptotic relative efficiency as the reciprocal ratio of the sample sizes required for two test procedures, for the same null and alternative hypothesis, and attaining the same power at the same significance level, can be extended to the test procedures considered here for two different null and alternative hypotheses. A simulation to study the relationship between asymptotic relative efficiency and finite sample sizes is carried out.

• Referencias bibliográficas
  • Ferreira-Gonz ́alez, I., Permanyer-Miralda, G., Busse, J.W., Bryant, D.M., Montori, V.M., Alonso-Coello,P., Walter, S.D. and Guyatt, G.H....
  • Freedman, L.S. (1982). Tables of the number of patients required in clinical trials using the logrank test.Statistics in Medicine, 1, 121–129.
  • Freemantle, N., Calvert, M., Wood, J., Eastaugh, J. and Griffin, C. (2003). Composite outcomes in Ran-domized Trials. Greater precision but...
  • G ́omez, G. (2011). Some theoretical thoughts when using a composite endpoint to prove the efficacy of atreatment.International Workshop on...
  • G ́omez, G., G ́omez-Mateu, M. and Dafni, U. (2014). InformedChoice of Composite End Points inCardiovascular Trials.Circulation. Cardiovascular...
  • G ́omez, G. and Lagakos, S.W. (2013). Statistical considerations when using a composite endpoint forcomparing treatment groups.Statistics...
  • Lehmann, E.L. and Romano, J.P. (2005).Testing Statistical Hypotheses, 3rd Ed. Springer.
  • Lindner, A.M. and Szimayer, A. (2005). A limit theorem for copulas.Sonderforschungsbereich 386, Paper433. http://epub.ub.uni-muenchen.de/1802....
  • Montori, V.M., Permanyer-Miralda, G., Ferreira-Gonz ́alez, I., Busse, J.W., Pacheco-Huergo, V., Bryant, D.,Alonso, J., Akl, E.A., Domingo-Salvany,...
  • Plana-Ripoll, O. and G ́omez, G. (2014). Extension of the AREmethod to select the Primary Endpoint in aRandomized Clinical Trial.Submitted.
  • Schoenfeld, D. (1981). The Asymptotic Properties of Nonparametric Tests for Comparing Survival Distri-butions.Biometrika, 68, 316–319.
  • Wittkop, L., Smith, C., Fox, Z., Sabin, C., Richert, L., Aboulker, J.P., Phillips, A., Chˆene, G., Babiker, A.and Thi ́ebaut, R. on behalf...