We study the variation of relative cohomology for a pair consisting of a smooth projective hypersurface and an algebraic subvariety in it. We construct an inhomogeneous Picard-Fuchs equation by applying a Picard-Fuchs operator to the holomorphic top form on a Calabi-Yau hypersurface in toric variety, and deriving a general formula for the $d$-exact form on one side of the equation. We also derive a double residue formula, giving a purely algebraic way to compute the inhomogeneous Picard-Fuchs equations for the Abel-Jacobi map, which has played an important role in the recent study of D-branes (by Morrison and Walcher). Using the variation formalism, we prove that the relative periods of toric B-branes on Calabi-Yau hypersurface satisfy the enhanced GKZ-hypergeometric system proposed in physics literature (by Alim, Hecht, Mayr, and Mertens), and discuss the relations between several works in the recent study of open string mirror symmetry. We also give the general solutions to the enhanced hypergeometric system.
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