The paper begins by overviewing the basic facts on geometric exceptional collections. Then we derive, for any coherent sheaf on a smooth projective variety with a geometric collection, two spectral sequences: the first one abuts to and the second one to its cohomology. The main goal of the paper is to generalize Castelnuovo-Mumford regularity for coherent sheaves on projective spaces to coherent sheaves on smooth projective varieties X with a geometric collection s. We define the notion of regularity of a coherent sheaf on X with respect to s. We show that the basic formal properties of the Castelnuovo-Mumford regularity of coherent sheaves over projective spaces continue to hold in this new setting and we show that in case of coherent sheaves on and for a suitable geometric collection of coherent sheaves on both notions of regularity coincide. Finally, we carefully study the regularity of coherent sheaves on a smooth quadric hypersurface (n odd) with respect to a suitable geometric collection and we compare it with the Castelnuovo-Mumford regularity of their extension by zero in .
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